IN-1130
SIGMA/SML1403 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 868612-83-3
Empirical Formula (Hill Notation): C25H20N6O
Molecular Weight: 420.47
Linear Formula: C25H20N6O
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C25H20N6O/c1-15-4-2-7- |
| InChI key | RYKSGWSKILPDDY-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [nH]1c(nc(c1c4cc5nccnc5cc |
| solubility | DMSO: 10 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGFβ1 recptor). |
| Biochem/physiol Actions: | IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGF1β recptor). The compound inhibits phosphorylation of Smad-2 with an IC50 of 36 nM. IN-1130 inhibits renal fibrosis, and also reduces tumor volume in prostate tumor xenografts in murine models. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |