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A01 (Smurf1 inhibitor)

SIGMA/SML1404 - ≥98% (HPLC)

Synonym: [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone

CAS Number: 1007647-73-5
Empirical Formula (Hill Notation): C22H20ClF3N4O3S
Molecular Weight: 512.93
MDL Number: MFCD09320899
Linear Formula: C22H20ClF3N4O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1404-5MG 5 mg
 $126.00
1/EA		 Add To Favorites
45-SML1404-25MG 25 mg
 $509.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3
InChI key QFYLTUDRXBNZFQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=S(C1=CC=C(Cl)C(C(F)(F)F)=C1)(N2CCN(C(C3=CC=C(N4N=CC=C4C)C=C3)=O)CC2)=O
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: A01 is a high affinity selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) that disturbs Smurf1-Smad1/5 interaction and blocks Smurf1 mediated Smad1/5 ubiquitination. A01 increases responsiveness to BMP-2 in myoblasts and osteoblasts.
Biochem/physiol Actions: A01 is a high affinity selective inhibitor of E3 ubiquitin-protein ligase Smurf1.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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