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(R)-PFI-2

SIGMA/SML1408 - ≥97% (HPLC)

Synonym: (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride

CAS Number: 1627607-87-7
Empirical Formula (Hill Notation): C23H25F4N3O3S · HCl
Molecular Weight: 535.98
Linear Formula: C23H25F4N3O3S · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1408-5MG 5 mg
 $217.00
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45-SML1408-25MG 25 mg
 $848.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m1./s1
InChI key ZADKZNVAJGEFLC-ZMBIFBSDSA-N
Quality Level 100 
SMILES string FC1=C2C(CCNC2)=CC(S(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)(=O)=O)=C1.[H]Cl
solubility DMSO: 10 mg/mL, clear (warmed)
storage temp. 2-8°C
Biochem/physiol Actions: (R)-PFI-2 is a histone-lysine N-methyltransferase (HKMT) inhibitor selective for SETD7 (also known as SET9).
Biochem/physiol Actions: (R)-PFI-2 is a histone-lysine N-methyltransferase (HKMT) inhibitor selective for SETD7 (also known as SET9). (R)-PFI-2 has an IC50 value of 2 nM and 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. For full characterization details, please visit the PFI-2 probe summary  on the Structural Genomics Consortium (SGC) website.

(S)-PFI-2, an enantiomer of (R)-PFI-2, is used as a negative control. (S)-PFI-2 is available from Sigma. To learn more about and purchase (S)-PFI-2, click here .

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc 
Features and Benefits: (R)-PFI-2 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: (R)-PFI-2 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the (R)-PFI-2 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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