Synonym: 2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-3H-pyrimidin-4-one; 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone (9CI); 4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-(9CI); 4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-; DDD00107587; RNAsplicing inhibitor
CAS Number: 374913-63-0
Empirical Formula (Hill Notation): C16H17N5O2
Molecular Weight: 311.34
MDL Number: MFCD02233199
Linear Formula: C16H17N5O2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
, white to dark brown |
| form |
powder |
| InChI |
1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22) |
| InChI key |
QQJIYKXTEMDJFM-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CC1=NC(NC(NC(C)=C2C)=NC2=O)=NC3=CC(OC)=CC=C31 |
| solubility |
DMSO: 0.5 mg/mL, clear (warmed) |
| storage temp. |
2-8°C |
| Application: |
Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells. |
| Biochem/physiol Actions: |
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex. |
| Biochem/physiol Actions: |
Madrasin is a potent and cell penetrant splicing inhibitor. |
| Biochem/physiol Actions: |
Madrasin is considered toxic to the cell at a higher concentration. At its minimal concentration, madrasin is known to induce subnuclear protein localization and cause cell cycle arrest. |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Precautionary statements |
P301 + P312 + P330 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
