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Madrasin

SIGMA/SML1409 - ≥98% (HPLC)

Synonym: 2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-3H-pyrimidin-4-one; 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone (9CI); 4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-(9CI); 4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-; DDD00107587; RNAsplicing inhibitor

CAS Number: 374913-63-0
Empirical Formula (Hill Notation): C16H17N5O2
Molecular Weight: 311.34
MDL Number: MFCD02233199
Linear Formula: C16H17N5O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1409-5MG 5 mg
 $129.00
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assay ≥98% (HPLC)
color , white to dark brown
form powder
InChI 1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)
InChI key QQJIYKXTEMDJFM-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC1=NC(NC(NC(C)=C2C)=NC2=O)=NC3=CC(OC)=CC=C31
solubility DMSO: 0.5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.
Biochem/physiol Actions: Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.
Biochem/physiol Actions: Madrasin is a potent and cell penetrant splicing inhibitor.
Biochem/physiol Actions: Madrasin is considered toxic to the cell at a higher concentration. At its minimal concentration, madrasin is known to induce subnuclear protein localization and cause cell cycle arrest.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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