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A-366

SIGMA/SML1410 - ≥98% (HPLC)

Synonym: 5′-Methoxy-6′-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3′-[3H]indol]-2′-amine

CAS Number: 1527503-11-2
Empirical Formula (Hill Notation): C19H27N3O2
Molecular Weight: 329.44
MDL Number: MFCD28133403
Linear Formula: C19H27N3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1410-5MG 5 mg
 $126.00
1/EA		 Add To Favorites
45-SML1410-25MG 25 mg
 $495.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
InChI key BKCDJTRMYWSXMC-UHFFFAOYSA-N
Quality Level 100 
SMILES string NC1=NC2=CC(OCCCN3CCCC3)=C(OC)C=C2C14CCC4
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC50 values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary  on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc 
Biochem/physiol Actions: A-366 is potent, selective inhibitor of the histone methyltransferase G9a.
Features and Benefits: A-366 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: A-366 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the A-366 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
Symbol GHS09  GHS09
Signal word Warning
Hazard statements H400
Precautionary statements P273 - P391
Hazard Codes N
Risk Statements 50
Safety Statements 61
RIDADR UN 3077 9 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352202

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