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KRIBB11 trifluoroacetate salt

SIGMA/SML1412 - ≥98% (HPLC)

Synonym: 2,6-Pyridinediamine trifluoroacetate salt; N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine trifluoroacetate salt; N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine trifluoroacetate salt

CAS Number: 342639-96-7 (free base)
Empirical Formula (Hill Notation): C13H12N6O2 · C2HF3O2
Molecular Weight: 398.30
Linear Formula: C13H12N6O2 · C2HF3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1412-25MG 25 mg
 $288.00
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assay ≥98% (HPLC)
color yellow to orange
form powder
InChI 1S/C13H12N6O2.C2HF3O2/c1-14-12-5-4-11(19(20)21)13(17-12)16-9-2-3-10-8(6-9)7-15-18-10;3-2(4,5)1(6)7/h2-7H,1H3,(H,15,18)(H2,14,16,17);(H,6,7)
InChI key DNBQMABUWGNHGB-UHFFFAOYSA-N
Quality Level 100 
SMILES string CNC1=NC(NC2=CC=C(NN=C3)C3=C2)=C([N+]([O-])=O)C=C1.FC(F)(C(O)=O)F
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: KRIBB11 is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1) with an IC50 value of 1.2 μM. KRIBB11 blocks induction of HSF1 downstream target proteins such as HSP27 and HSP70 by impairing the recruitment of Positive Transcription Elongation Factor b (P-TEFb) to the HSF1 transcriptional complex, preventing HSF1-mediated gene expression KRIBB11 inhibits tumor growth in vivo and acts synergistically to increase apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin and 17-AAG.
Biochem/physiol Actions: KRIBB11 is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1).
Biochem/physiol Actions: KRIBB11 is capable of preventing the proliferation of cancer cells. It has the ability to stimulate apoptosis and can arrest the cell cycle at G2/M phase.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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