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Liproxstatin-1

SIGMA/SML1414 - >98% (HPLC)

Synonym: N-[(3-Chlorophenyl)methyl]-spiro[piperidine-4,2′(1′H)-quinoxalin]-3′-amine; N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4′-piperidine]-2-amine

CAS Number: 950455-15-9
Empirical Formula (Hill Notation): C19H21ClN4
Molecular Weight: 340.85
MDL Number: MFCD14948691
Linear Formula: C19H21ClN4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1414-5MG 5 mg
 $123.00
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45-SML1414-25MG 25 mg
 $484.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1414-5MG.

 

assay >98% (HPLC)
color white to light brown
form powder
InChI 1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
InChI key YAFQFNOUYXZVPZ-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1
solubility DMSO: 10 mg/mL, clear
storage temp. −20°C
Application: Liproxstatin-1 has been used as a cell death inhibitor in the cell viability assay and for the determination of lipid peroxidation.
Biochem/physiol Actions: Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.
Biochem/physiol Actions: Liproxstatin-1 is a potent inhibitor of ferroptosis.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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