Synonym: N-[(3-Chlorophenyl)methyl]-spiro[piperidine-4,2′(1′H)-quinoxalin]-3′-amine; N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4′-piperidine]-2-amine
CAS Number: 950455-15-9
Empirical Formula (Hill Notation): C19H21ClN4
Molecular Weight: 340.85
MDL Number: MFCD14948691
Linear Formula: C19H21ClN4
Product Type: Chemical
| assay |
>98% (HPLC) |
| color |
white to light brown |
| form |
powder |
| InChI |
1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23) |
| InChI key |
YAFQFNOUYXZVPZ-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
ClC1=CC(CNC2=NC3=CC=CC=C3NC24CCNCC4)=CC=C1 |
| solubility |
DMSO: 10 mg/mL, clear |
| storage temp. |
−20°C |
| Application: |
Liproxstatin-1 has been used as a cell death inhibitor in the cell viability assay and for the determination of lipid peroxidation. |
| Biochem/physiol Actions: |
Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice. |
| Biochem/physiol Actions: |
Liproxstatin-1 is a potent inhibitor of ferroptosis. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
>98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
