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KU-60019

SIGMA/SML1416 - ≥97% (HPLC)

Synonym: (2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide

CAS Number: 925701-49-1
Empirical Formula (Hill Notation): C30H33N3O5S
Molecular Weight: 547.67
MDL Number: MFCD19690944
Linear Formula: C30H33N3O5S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1416-5MG 5 mg
 $129.00
1/EA		 Add To Favorites
45-SML1416-25MG 25 mg
 $509.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
InChI key SCELLOWTHJGVIC-BGYRXZFFSA-N
Quality Level 100 
SMILES string O=C(CN1C[C@H](C)O[C@H](C)C1)NC(C=C2)=CC3=C2SC4=C(C5=CC(C=C(N6CCOCC6)O5)=O)C=CC=C4C3
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Application: KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death.
Biochem/physiol Actions: KU-60019 is a potent inhitor of ATM (ataxia telangiectasia mutated) kinase, a member of phosphatidylinositol-3-kinase-related kinase family that is critical in regulating cell cycle checkpoints and DNA repair. KU-60019 has an IC50 value of 6.3 nM. KU-60019 radiosensitizes U1242 human glioma cells, and also blocks U1242 cell migration and invasion through matrigel.
Biochem/physiol Actions: KU-60019 is a potent inhitor of ATM (ataxia telangiectasia mutated) kinase.
Other Notes: KU-60019 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the KU-60019 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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