EPZ015666

SIGMA/SML1421 - ≥98% (HPLC)

Synonym: (S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide; GSK3235025; YQ36286

CAS Number: 1616391-65-1
Empirical Formula (Hill Notation): C₂₀H₂₅N₅O₃
Molecular Weight: 383.44
MDL Number: MFCD28411588
Linear Formula: C₂₀H₂₅N₅O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1421-5MG	5 mg	$257.00 1/EA	Add To Favorites
45-SML1421-25MG	25 mg	$998.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1
InChI key	ZKXZLIFRWWKZRY-KRWDZBQOSA-N
Quality Level	100
SMILES string	O[C@H](CN1CCC(C=CC=C2)=C2C1)CNC(C3=CC(NC4COC4)=NC=N3)=O
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	EPZ015666 (GSK3235025) is a protein arginine methyltransferase PRMT5 inhibitor with an IC₅₀ value of of 22 nM in biochemical assays and no inhibition up to the maximum tested concentration of 50 μM against a panel of 20 other protein methyltransferases. Inhibition was uncompetitive with respect to SAM. EPZ015666 showed dose-dependent antitumor activity in multiple in vitro and in vivo mantle cell lymphoma (MCL) models with treatment of MCL cell lines leading to inhibition of SmD3 methylation and cell death.
Biochem/physiol Actions:	EPZ015666 (GSK3235025) is a protein arginine methyltransferase PRMT5 inhibitor.
Other Notes:	EPZ015666 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the EPZ015666 probe summary on the Chemical Probes Portal website.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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