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Ac-YVAD-pNA

SIGMA/SML1424 - ≥98% (HPLC)

Synonym: Caspase-1 substrate (Chromogenic); N-α-acetyl-Tyr-Val-Ala-Asp-p-nitroanilide; N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine

CAS Number: 149231-66-3
Empirical Formula (Hill Notation): C29H36N6O10
Molecular Weight: 628.63
MDL Number: MFCD00274387
Linear Formula: C29H36N6O10
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1424-5MG 5 mg
 $111.00
1/EA		 Add To Favorites
45-SML1424-25MG 25 mg
 $444.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C29H36N6O10/c1-15(2)25(34-28(42)22(31-17(4)36)13-18-5-11-21(37)12-6-18)29(43)30-16(3)26(40)33-23(14-24(38)39)27(41)32-19-7-9-20(10-8-19)35(44)45/h5-12,15-16,22-23,25,37H,13-14H2,1-4H3,(H,30,43)(H,31,36)(H,32,41)(H,33,40)(H,34,42)(H,38,39)/t16-,22-,23-,25-/m0/s1
InChI key YDPNOCSPPGFBPX-XNHCRPTKSA-N
Quality Level 100 
SMILES string O=C([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC1=CC=C(O)C=C1)=O)=O)=O)NC2=CC=C([N+]([O-])=O)C=C2
storage temp. −20°C
Biochem/physiol Actions: Ac-YVAD-pNA is a chromogenic selective caspase-1 substrate
Biochem/physiol Actions: Ac-YVAD-pNA is a very selective chromogenic substrate for caspase-1, a key mediator of inflammatory processes formerly known as interleukin (IL)-1-converting enzyme. Ac-YVAD-pNA is used to determine caspase-1 activity. Cleavage of Ac-YVAD-pNA by caspase-1 releases pNA (p-nitroanilide), which can be quantified spectrophotometrically at 405 nm.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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