AZ3146

SIGMA/SML1427 - ≥98% (HPLC)

Synonym: 9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one; AZ-3146

CAS Number: 1124329-14-1
Empirical Formula (Hill Notation): C₂₄H₃₂N₆O₃
Molecular Weight: 452.55
MDL Number: MFCD18384959
Linear Formula: C₂₄H₃₂N₆O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1427-5MG	5 mg	$138.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
InChI key	YUKWVHPTFRQHMF-UHFFFAOYSA-N
Quality Level	100
SMILES string	CN1CCC(OC2=CC(OC)=C(NC3=NC=C4C(N(C5CCCC5)C(N4C)=O)=N3)C=C2)CC1
solubility	DMSO: 2 mg/mL, clear (warmed)
storage temp.	2-8°C

Biochem/physiol Actions:	AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC₅₀ = 35 nM), an important regulator of Spindle Assembly Checkpoint (SAC). AZ3146 treated HeLa cells override SAC, and quickly enter mitosis, with a reduced mitosis completion time of 32 minutes. 50% of treated cells entered anaphase without complete chromosomal alignment.
Biochem/physiol Actions:	AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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