SPP86

SIGMA/SML1435 - ≥98% (HPLC)

Synonym: 1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS Number: 1357349-91-7
Empirical Formula (Hill Notation): C₁₆H₁₅N₅
Molecular Weight: 277.32
MDL Number: MFCD23379049
Linear Formula: C₁₆H₁₅N₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1435-5MG	5 mg	$124.00 1/EA		Add To Favorites
45-SML1435-25MG	25 mg	$488.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
InChI key	JQOIRTDBHMDWMT-UHFFFAOYSA-N
Quality Level	100
SMILES string	NC1=NC=NC2=C1C(C#CC3=CC=CC=C3)=NN2C(C)C
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC₅₀ value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 μM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC₅₀ value of 1.0 μM, similar to tamoxifen.
Biochem/physiol Actions:	SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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