Pimecrolimus

SIGMA/SML1437 - ≥97% (HPLC)

Synonym: 33-epi-chloro-33-desoxyascomycin; Picrolimus

CAS Number: 137071-32-0
Empirical Formula (Hill Notation): C₄₃H₆₈ClNO₁₁
Molecular Weight: 810.45
MDL Number: MFCD00901792
Linear Formula: C₄₃H₆₈ClNO₁₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1437-10MG	10 mg	$144.00 1/EA		Add To Favorites
45-SML1437-50MG	50 mg	$574.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to beige
form	powder
InChI	1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-31(44)35(22-29)52-7/h18,20,25,27-33,35-39,46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32-,33-,35+,36-,37-,38+,39+,43+/m0/s1
InChI key	KASDHRXLYQOAKZ-XDSKOBMDSA-N
Quality Level	100
SMILES string	C[C@H]([C@@H](O)CC([C@H](CC)/C=C1C)=O)[C@](/C(C)=C/[C@@]2([H])C[C@@H](OC)[C@@H](Cl)CC2)([H])OC([C@@]3([H])N(C(C([C@@]4(O)[C@H](C)C[C@H](OC)[C@@H]([C@@H](OC)C[C@@H](C)C1)O4)=O)=O)CCCC3)=O
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	Calcineurin inhibitor, immune suppressant
Biochem/physiol Actions:	Pimecrolimus is known for its anti-inflammatory and immunomodulatory properties and its low systemic immunosuppressive potential.
Biochem/physiol Actions:	Pimecrolimus, also known as Picrolimus, is a macrolactam ascomycin derivative that acts as an immune suppressant. It binds with high affinity to macrophilin-12 (FKBP-12) and inhibits calcineurin, a calcium-dependent phosphatase. Pimecrolimus inhibits production of pro-inflammatory cytokines by T cells and mast cells and prevents the release of inflammatory cytokines and mediators from mast cells. It has been used clinically as a treatment for eczema.
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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