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(Z-LL)2 Ketone

SIGMA/SML1442 - ≥98% (HPLC)

Synonym: (Z-Leu-Leu-NHCH2)2CO; 1,3-Di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone; 2,2′-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide

CAS Number: 313664-40-3
Empirical Formula (Hill Notation): C43H64N6O9
Molecular Weight: 809.00
MDL Number: MFCD04974180
Linear Formula: C43H64N6O9
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1442-1MG 1 mg
 $73.60
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color white to light yellow
form powder
InChI 1S/C43H64N6O9/c1-27(2)19-34(46-40(53)36(21-29(5)6)48-42(55)57-25-31-15-11-9-12-16-31)38(51)44-23-33(50)24-45-39(52)35(20-28(3)4)47-41(54)37(22-30(7)8)49-43(56)58-26-32-17-13-10-14-18-32/h9-18,27-30,34-37H,19-26H2,1-8H3,(H,44,51)(H,45,52)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t34-,35-,36-,37-/m0/s1
InChI key JTVCWQUNPMKMER-BQYLNSIHSA-N
Quality Level 100 
shipped in wet ice
SMILES string O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)OCC2=CC=CC=C2
storage temp. −20°C
Biochem/physiol Actions: (Z-LL)2 Ketone is a selective inhibitor of signal peptide peptidase (SPP) that inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
Biochem/physiol Actions: (Z-LL)2 Ketone is a selective inhibitor of signal peptide peptidase (SPP).
Biochem/physiol Actions: (Z-LL)2 Ketone serves as an inverse γ-secretase modulator (iGSM) by changing processivity of γ-secretase cleavage.
Packaging: 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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