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Clemizole hydrochloride

SIGMA/SML1447 - ≥98% (HPLC)

Synonym: 1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride; 1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride; 1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride; CID 2782 hydrochloride; NSC 46261 hydrochloride

CAS Number: 1163-36-6
Empirical Formula (Hill Notation): C19H20ClN3 · HCl
Molecular Weight: 362.30
EC Number: 214-605-4
MDL Number: MFCD00051435
Linear Formula: C19H20ClN3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1447-5MG 5 mg
 $111.00
1/EA		 Add To Favorites
45-SML1447-25MG 25 mg
 $444.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H
InChI key DNFMJYXRIMLMBZ-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.[H]Cl
solubility H2O: 2 mg/mL, clear (warmed)
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.
Biochem/physiol Actions: Clemizole is a potent and preferring inhibitor of TRPC5; Antihistaminic.
Biochem/physiol Actions: Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment.
General description: Clemizole is a potent anti-allergic drug.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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