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Lonafarnib

SIGMA/SML1457 - ≥98% (HPLC)

Synonym: 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5Hbenzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide; SCH-66336; SCH66336

CAS Number: 193275-84-2
Empirical Formula (Hill Notation): C27H31Br2ClN4O2
Molecular Weight: 638.82
MDL Number: MFCD06795138
Linear Formula: C27H31Br2ClN4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1457-5MG 5 mg
 $148.00
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45-SML1457-25MG 25 mg
 $535.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1457-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
InChI key DHMTURDWPRKSOA-RUZDIDTESA-N
Quality Level 100 
SMILES string O=C(N)N(CC1)CCC1CC(N2CCC([C@H]3C(N=CC(Br)=C4)=C4CCC5=C3C(Br)=CC(Cl)=C5)CC2)=O
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: Lonafarnib is a potent inhibitor of farnesyltransferase, an enzyme responsible for a post-translational modification of proteins (including Ras) that gives a protein sufficient hydrophobicity to translocate to the plasma membrane. Farnesylation regulates signaling cascades controlling cell survival, proliferation and differentiation, so variety of possible uses is not surprising a post-translational modification of proteins (including Ras) that gives a protein sufficient hydrophobicity to translocate to the plasma membrane. Lonafarnib has been studies for possible treatment of progeria, various cancers, and hepatitis D.
Biochem/physiol Actions: Lonafarnib is a potent inhibitor of farnesyltransferase.
Biochem/physiol Actions: Lonafarnib prevents the post-translational lipid modification of H-Ras and other farnesylated proteins. Lonafarnib treatment results in microtubule bundling, increased microtubule acetylation and stabilization and suppression of microtubule dynamics.
General description: Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI). K- and N-Ras are substrates of farnesyl transferase.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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