NHI-2
SIGMA/SML1463 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 1269802-97-2
Empirical Formula (Hill Notation): C17H12F3NO3
Molecular Weight: 335.28
Linear Formula: C17H12F3NO3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C17H12F3NO3/c1-24-16(2 |
InChI key | YPPFWRWCZNXINO-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | ON(C(C(OC)=O)=C1)C2=C1C(C |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | NHI-2 is an inihbitor of Lactate dehydrogenase-A (LDH-A, LDHA), a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth and proliferation (the Warburg effect). NHI-2 has anti-glycolytic activity against a variety of cancer cells. NHI-2 inhibited cell growth of pancreatic cancer LPC006 and PANC-1 cells and enhanced the antiproliferative effects of Gemcitabine and caused apoptosis in colon cancer HCT116 cells. |
Biochem/physiol Actions: | NHI-2 possesses highr cell permeability. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |