SMBA1

SIGMA/SML1464 - ≥98% (HPLC)

Synonym: 2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol; 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol

CAS Number: 906440-37-7
Empirical Formula (Hill Notation): C₂₀H₁₃NO₃
Molecular Weight: 315.32
Linear Formula: C₂₀H₁₃NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1464-5MG	5 mg	$115.00 1/EA		Add To Favorites
45-SML1464-25MG	25 mg	$0.00 1/EA CALL FOR PRICE		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H/b18-11+
InChI key	PEYKRJBXACUOOB-WOJGMQOQSA-N
Quality Level	100
SMILES string	OC(C=CC=C1)=C1/C=C2C(C=CC=C3)=C3C4=C2C=C([N+]([O-])=O)C=C4
solubility	DMSO: 20 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist that binds to Bax, induces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members.
Biochem/physiol Actions:	SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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