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ABH hydrochloride

SIGMA/SML1466 - ≥98% (HPLC)

Synonym: 2(S)-Amino-6-boronohexanoic acid hydrochloride; 6-Borono-L-norleucine hydrochloride

CAS Number: 194656-75-2
Empirical Formula (Hill Notation): C6H14BNO4 · HCl
Molecular Weight: 211.45
MDL Number: MFCD22887376
Linear Formula: C6H14BNO4 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1466-5MG 5 mg
 $190.00
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45-SML1466-25MG 25 mg
 $722.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
InChI key XCUVEZUCSHVMRK-JEDNCBNOSA-N
optical activity [α]/D +8 to +13°, c = 0.7 in H2O
Quality Level 100 
SMILES string OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
solubility H2O: 20 mg/mL, clear
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.
Biochem/physiol Actions: Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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