ASP7663

SIGMA/SML1467 - ≥98% (HPLC)

Synonym: (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid; (E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid

CAS Number: 1190217-35-6
Empirical Formula (Hill Notation): C₁₄H₁₄FNO₃
Molecular Weight: 263.26
Linear Formula: C₁₄H₁₄FNO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1467-5MG	5 mg	$144.00 1/EA	Add To Favorites
45-SML1467-25MG	25 mg	$435.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	light orange to dark orange
form	powder
InChI	1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+
InChI key	RCVZUIGCNAAMIC-UXBLZVDNSA-N
Quality Level	100
SMILES string	CC(C)CN(C1=C(F)C=CC=C1/C2=CC(O)=O)C2=O
solubility	DMSO: 25 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC₅₀ values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.
Biochem/physiol Actions:	ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1).
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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