Synonym: (17a)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile; 17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile; 17-cyanomethyl-17-hydroxy-estra-4,9-dien-3-one
CAS Number: 65928-58-7
Empirical Formula (Hill Notation): C20H25NO2
Molecular Weight: 311.42
MDL Number: MFCD00868356
Linear Formula: C20H25NO2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1 |
| InChI key |
AZFLJNIPTRTECV-FUMNGEBKSA-N |
| optical activity |
[α]/D -305 to -325°, c = 1 in dichloromethane |
| Quality Level |
100  |
| SMILES string |
O[C@@]1(CC#N)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3CC[C@@]21C)=O |
| solubility |
DMSO: 5 mg/mL, clear (warmed) |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Dienogest is a fourth-generation progestin, an orally active synthetic progestogen with approximately 10% of the relative affinity of progesterone, but has a very potent progestagenic effect in the endometrium with some antiandrogenic activity and without any androgenic, glucocorticoid or mineralocorticoid effects. It has been used alone or in combination as a contraceptive and to treat uterine fibroids. Dienogest inhibits ovulation primarily through peripheral action rather than by central action on gonadotrophin secretion. |
| Biochem/physiol Actions: |
Dienogest is used to treat endometriosis. It might also help to decrease the levels of plasma estradiol by stimulating cell death of granulosa cells in the ovary. |
| Packaging: |
10, 50 mg in glass bottle |
| Symbol |
 GHS08 |
| Signal word |
Warning |
| Hazard statements |
H361 |
| Precautionary statements |
P280 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
