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SN50 trifluoroacetate salt

SIGMA/SML1471 - ≥95% (HPLC)

Synonym: AAVALLPAVLLALLAPVQRKRQKLMP trifluoroacetate salt; H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH trifluoroacetate salt; NF-KB SN50 cell permeable inhibitory peptide trifluoroacetate salt; Nuclear Factor NF-KB Inhibitor SN50 trifluoroacetate salt

CAS Number: 213546-53-3 (free base)
Empirical Formula (Hill Notation): C129H230N36O29S · xC2HF3O2
Molecular Weight: 2781.50 (free base basis)
Linear Formula: C129H230N36O29S · xC2HF3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1471-1MG 1 mg
 $273.00
1/EA		 Add To Favorites
assay ≥95% (HPLC)
color white
form film
Quality Level 100 
shipped in wet ice
storage temp. −20°C
Application: SN50 trifluoroacetate salt has been used as a nuclear factor-kappa B (NF-κB) inhibitor:
• to study its effects on the reactive oxygen species generation in human keratinocytes
• to analyze its effects on mRNA expression in the receptor for advanced glycation end products (RAGE) in hCMEC/D3 blood-brain barrier (BBB) cell line
• to study its effects on macrophage polarization
Biochem/physiol Actions: SN50 is an NF-κB cell permeable inhibitory peptide. The SN50 sequence contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NFκB p50 linked to a peptide cell-permeabilization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). SN50 Peptide inhibits translocation of the NF-κB active complex into the nucleus.
Packaging: 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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