Thiocolchicoside
SIGMA/SML1476 - ≥98% (HPLC)
Synonym: (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide; 2-
CAS Number: 602-41-5
Empirical Formula (Hill Notation): C27H33NO10S
Molecular Weight: 563.62
EC Number: 210-017-7
MDL Number: MFCD07995056
Linear Formula: C27H33NO10S
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1476-25MG.
This image depicts SML1476-25MG.
| assay | ≥98% (HPLC) |
| color | light yellow to dark yellow |
| form | powder |
| InChI | 1S/C27H33NO10S/c1-12(30)2 |
| InChI key | LEQAKWQJCITZNK-AXHKHJLKSA |
| optical activity | [α]/D -510 to -610°, c = 0.5 in H2O |
| Quality Level | 100  |
| SMILES string | O[C@H]1[C@H](O)[C@@H](CO) |
| solubility | H2O: 10 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Thiocolchicoside acts as a muscle relaxant. In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol. Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones. |
| Biochem/physiol Actions: | Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. |
| Biochem/physiol Actions: | Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF- |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301 - H341 - H361fd - H372 |
| Precautionary statements | P201 - P301 + P310 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |