MPI-0479605 hydrochloride
SIGMA/SML1477 - ≥98% (HPLC)
Synonym: N6-
CAS Number: 1246529-32-7 (free base)
Empirical Formula (Hill Notation): C22H29N7O · HCl
Molecular Weight: 443.97
MDL Number: MFCD28155089
Linear Formula: C22H29N7O · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C22H29N7O.ClH/c1-15-13 |
InChI key | BYBIFMLUJUNGNX-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | CC(C=C(N1CCOCC1)C=C2)=C2N |
solubility | DMSO: 5 mg/mL, clear (warmed) |
storage temp. | −20°C |
Biochem/physiol Actions: | MPI-0479605 is a potent ATP-competitive inhibitor of the dual-specificity kinase Mps-1, which is essential for maintainence of spindle assembly checkpoint and chromalomal spindle attachment. Treatment of cells with MPI-0479605 causes aberrant mitosis and aneuploidy and inhibits growth of tumor xenografts in vivo. MPI-0479605 has an IC50 value of 1.8 nM. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301 + P330 + P331 + P310 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |