Synonym: 2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-benzenemethanol; [2-[4-Amino-6-(benzylamino)-1,3,5-triazin-2-yl]phenyl]methanol
CAS Number: 1309198-71-7
Empirical Formula (Hill Notation): C17H17N5O
Molecular Weight: 307.35
Linear Formula: C17H17N5O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22) |
| InChI key |
MDGIEDNDSFMSLP-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1 |
| solubility |
DMSO: 25 mg/mL, clear |
| storage temp. |
2-8°C |
| Application: |
Ogerin has been used in G-protein-coupled receptors (GPCR) deorphanization and phosphatidylinositol hydrolysis assay. |
| Biochem/physiol Actions: |
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory. |
| Packaging: |
5, 25 mg in glass bottle |
| Recommended products: |
Ogerin negative control, a structurally similar analog of ogerin, is available from Sigma. To learn more about and purchase ogerin negative control, click here . |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
