Ogerin

SIGMA/SML1482 - ≥98% (HPLC)

Synonym: 2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-benzenemethanol; [2-[4-Amino-6-(benzylamino)-1,3,5-triazin-2-yl]phenyl]methanol

CAS Number: 1309198-71-7
Empirical Formula (Hill Notation): C₁₇H₁₇N₅O
Molecular Weight: 307.35
Linear Formula: C₁₇H₁₇N₅O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1482-5MG	5 mg	$119.00 1/EA	Add To Favorites
45-SML1482-25MG	25 mg	$480.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22)
InChI key	MDGIEDNDSFMSLP-UHFFFAOYSA-N
Quality Level	100
SMILES string	OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1
solubility	DMSO: 25 mg/mL, clear
storage temp.	2-8°C

Application:	Ogerin has been used in G-protein-coupled receptors (GPCR) deorphanization and phosphatidylinositol hydrolysis assay.
Biochem/physiol Actions:	Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1).
Biochem/physiol Actions:	Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.
Other Notes:	Ogerin negative control, a structurally similar analog of ogerin, is available from Sigma. To learn more about and purchase ogerin negative control, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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