SW033291

SIGMA/SML1485 - ≥98% (HPLC)

Synonym: 2-(Butane-1-sulfinyl)-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridin-3-ylamine

CAS Number: 459147-39-8
Empirical Formula (Hill Notation): C₂₁H₂₀N₂OS₃
Molecular Weight: 412.59
Linear Formula: C₂₁H₂₀N₂OS₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1485-5MG	5 mg	$182.00 1/EA	Add To Favorites
45-SML1485-25MG	25 mg	$582.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	light yellow to yellow-green
form	powder
InChI	1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
InChI key	LCYAYKSMOVLVRL-UHFFFAOYSA-N
Quality Level	100
SMILES string	NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	2-8°C

Biochem/physiol Actions:

SW033291 is an inhibitor of the prostaglandin-degrading enzyme 15-PGDH. PGE2 is known to promote hematopoiesis and to promote reeneration by causing stem cells to proliferate. 15-PGDH degrades prostaglandin PGE2 and is a negative regulator of tissue regeneration and repair. SW033291 inhibition of 15-PGDH doubled levels of PGE2 and doubled rates of colon and liver tissue regeneration. Mice given SW033291 after receiving a bone marrow transplant had a two- to threefold increase in the number of donor cells that homed to the their bone marrow.

Packaging:

5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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