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FICZ

SIGMA/SML1489 - ≥95% (HPLC)

Synonym: 5,11-Dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde; 6-Formylindolo[3,2-b]carbazole

CAS Number: 172922-91-7
Empirical Formula (Hill Notation): C19H12N2O
Molecular Weight: 284.31
Linear Formula: C19H12N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1489-1MG 1 mg
 $148.00
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45-SML1489-5MG 5 mg
 $599.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥95% (HPLC)
color yellow
form lyophilized powder
InChI 1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H
InChI key ZUDXFBWDXVNRKF-UHFFFAOYSA-N
Quality Level 100 
SMILES string [nH]1c2c(c5c1cccc5)cc3[nH]c4c(c3c2C=O)cccc4
solubility DMSO: 0.5 mg/mL, clear (warmed)
storage temp. −20°C
Biochem/physiol Actions: FICZ (6-formylindolo(3,2b)carbazole) being a photooxidation product of tryptophan, might serve as a chemical messenger of light.
Biochem/physiol Actions: FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
Biochem/physiol Actions: FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR).
Packaging: 1, 5 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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