Synonym: 5,11-Dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde; 6-Formylindolo[3,2-b]carbazole
CAS Number: 172922-91-7
Empirical Formula (Hill Notation): C19H12N2O
Molecular Weight: 284.31
Linear Formula: C19H12N2O
Product Type: Chemical
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| assay |
≥95% (HPLC) |
| color |
yellow |
| form |
lyophilized powder |
| InChI |
1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H |
| InChI key |
ZUDXFBWDXVNRKF-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
[nH]1c2c(c5c1cccc5)cc3[nH]c4c(c3c2C=O)cccc4 |
| solubility |
DMSO: 0.5 mg/mL, clear (warmed) |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
FICZ (6-formylindolo(3,2b)carbazole) being a photooxidation product of tryptophan, might serve as a chemical messenger of light. |
| Biochem/physiol Actions: |
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM. |
| Biochem/physiol Actions: |
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR). |
| Packaging: |
1, 5 mg in glass bottle |
| Symbol |
GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Precautionary statements |
P301 + P312 + P330 |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 1 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |