GW501516
SIGMA/SML1491 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 317318-70-0
Empirical Formula (Hill Notation): C21H18F3NO3S2
Molecular Weight: 453.50
MDL Number: MFCD09033000
Linear Formula: C21H18F3NO3S2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C21H18F3NO3S2/c1-12-9- |
| InChI key | YDBLKRPLXZNVNB-UHFFFAOYSA |
| Quality Level | 100  |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Application: | GW501516 has been used as a peroxisome proliferator-activated receptor (PPAR) δ agonist: • to treat the differentiated L6 myotubes to test its effect on free fatty acid (FFA) uptake under mild hypoxia conditions • in organoid culture medium to test its effect on self-renewal of PR domain containing 16 (Prdm16)-depleted intestinal stem cells • as a component in the defatting medium for primary human hepatocytes (PHH) culture |
| Application: | GW501516 has been used to study its effect on mutation-driven colorectal tumorigenesis and tumor invasion using mouse model. |
| Biochem/physiol Actions: | GW501516 is a selective Peroxisome Proliferator-Activated Receptor delta (PPARδ) agonist with high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ and > 1000 fold selectivity over PPARα and PPARγ. GW501516 was shown to activate some of the same pathways activated through exercise, and was investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. However, GW501516 also showed an increase in cancer in rats. |
| Biochem/physiol Actions: | PPARδ activation by GW501516, retards weight gain through fatty acid catabolism in adipose tissue and skeletal muscles. GW501516 causes an increase in the levels high-density lipoprotein cholesterol and apolipoprotein A (apoA) and reduction in the low density-lipoprotein cholesterol, apoB, and triglyceride. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |