UMI-77
SIGMA/SML1492 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 518303-20-3
Empirical Formula (Hill Notation): C18H14BrNO5S2
Molecular Weight: 468.34
MDL Number: MFCD03471890
Linear Formula: C18H14BrNO5S2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C18H14BrNO5S2/c19-11-5 |
InChI key | WUGANDSUVKXMEC-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | OC1=C(SCC(O)=O)C=C(NS(C2= |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | UMI-77 is an inhibitor of Induced myeloid leukemia cell differentiation protein Mcl-1, a member of the Bcl-2 family that inhibits apoptosis. UMI-77 acts by binding to the BH3-binding groove of Mcl-1, blocking the heterodimerization of Mcl-1/Bax and Mcl-1/Bak. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. It inhibited cell growth and induced apoptosis in pancreatic cancer cells. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS05,GHS07 |
Signal word | Danger |
Hazard statements | H302 - H315 - H318 - H335 |
Precautionary statements | P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |