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Canrenone

SIGMA/SML1497 - ≥97% (HPLC)

Synonym: (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone; NSC 261713

CAS Number: 976-71-6
Empirical Formula (Hill Notation): C22H28O3
Molecular Weight: 340.46
MDL Number: MFCD00071735
Linear Formula: C22H28O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1497-50MG 50 mg
 $80.70
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assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
InChI key UJVLDDZCTMKXJK-WNHSNXHDSA-N
optical activity [α]/D +17 to +24°, c = 1 in chloroform-d
Quality Level 100 
SMILES string C[C@@]12C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]45OC(CC5)=O)=CC(CC1)=O
solubility DMSO: 20 mg/mL, clear
storage temp. room temp
Biochem/physiol Actions: Canrenone is a mineralocorticoid (aldosterone) inhibitor.
Biochem/physiol Actions: Canrenone is a mineralocorticoid (aldosterone) inhibitor. Aldosterone is known to be involved in hypertension, kidney disease, atherosclerosis, and heart failure. Blockade of the aldosterone receptor has been shown to improve cardiovascular function. In congestive heart failure, aldosterone antagonists are used in addition to other drugs for additive diuretic effect, which reduces edema and the cardiac workload.
Canrenone is an active metabolite of spironolactone with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. It is known to reduce the inflammatory reaction influenced by aldosterone.
Packaging: 50 mg in glass bottle
Purity ≥97% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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