Synonym: N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylamino)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide; N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-benzamide
CAS Number: 839706-07-9
Empirical Formula (Hill Notation): C28H24F3N7O2
Molecular Weight: 547.53
Linear Formula: C28H24F3N7O2
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
Quality Level |
100 |
solubility |
DMSO: 2 mg/mL, clear (warmed) |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
GNF-7 is a multi-targeted kinase inhibitor that inhibits RAS signaling in addition to inhibiting the T315I “Gatekeeper” mutant of Bcr-Abl. GNF-7 inhibits NRAS-dependent cells in pre-clinical models of AML and ALL and inhibited T315I-Bcr-Abl dependent tumor growth in a murine model of CML. |
Packaging: |
5, 25 mg in glass bottle |
Symbol |
GHS06 |
Signal word |
Danger |
Hazard statements |
H301 |
Precautionary statements |
P301 + P330 + P331 + P310 |
RIDADR |
UN 2811 6.1 / PGIII |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |