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Apcin

SIGMA/SML1503 - ≥98% (HPLC)

Synonym: 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate; 3-(2-Methyl-5-nitro-imidazol-1-yl)-N-(2,2,2-trichloro-1-phenylamino-ethyl)-propionamide

CAS Number: 300815-04-7
Empirical Formula (Hill Notation): C13H14Cl3N7O4
Molecular Weight: 438.65
Linear Formula: C13H14Cl3N7O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1503-5MG 5 mg
 $165.00
1/EA		 Add To Favorites
45-SML1503-25MG 25 mg
 $660.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1503-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C13H14Cl3N7O4/c1-8-19-7-9(23(25)26)22(8)5-6-27-12(24)21-10(13(14,15)16)20-11-17-3-2-4-18-11/h2-4,7,10H,5-6H2,1H3,(H,21,24)(H,17,18,20)
InChI key ZEXHXVOGJFGTRX-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O
solubility DMSO: 25 mg/mL, clear
storage temp. room temp
Biochem/physiol Actions: Apcin is an inhibitor of the anaphase-promoting complex/cyclosome (APC/C), a large multimeric complex that functions as a ubiquitin ligase, initiating the metaphase–anaphase transition and regulating ordered transitions through the cell cycle by controlling the ubiquitin-mediated proteolysis of cell cycle proteins. Apcin prevents substrate recognition and inhibits APC/C-dependent ubiquitylation by binding to the D-box binding site of Cdc20, a coactivator required for full activation of APC/C and substrate recognition. The effectiveness of apcin in blocking mitotic exit was synergistically amplified by co-addition of TAME (tosyl-L-arginine methyl ester) or its cell permeable prodrug proTAME, which block Cdc20 binding to the APC/C at a different site than apcin.
Biochem/physiol Actions: Apcin is an inhibitor of the anaphase-promoting complex/cyclosome (APC/C).
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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