KY-05009

SIGMA/SML1506 - ≥98% (HPLC)

Synonym: 5-(4-Methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide; 5-[(4-Methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide

CAS Number: 1228280-29-2
Empirical Formula (Hill Notation): C₁₈H₁₆N₄O₂S
Molecular Weight: 352.41
Linear Formula: C₁₈H₁₆N₄O₂S
Product Type: Chemical

assay	≥98% (HPLC)
color	light yellow to dark yellow
form	powder
InChI	1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)
InChI key	WCEDGRTWDSHZHF-UHFFFAOYSA-N
Quality Level	100
SMILES string	NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
Biochem/physiol Actions:	KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable