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CRT0066101 hydrochloride

SIGMA/SML1507 - ≥98% (HPLC)

Synonym: 2-[4-((R)-2-Amino-butylamino)-pyrimidin-2-yl]-4-(1-methyl-1Hpyrazol-4-yl)-phenol hydrochloride; 2-[4-[[(2R)-2-Aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-phenol hydrochloride

CAS Number: 956123-34-5 (free base)
Empirical Formula (Hill Notation): C18H22N6O · xHCl
Molecular Weight: 338.41 (free base basis)
Linear Formula: C18H22N6O · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1507-5MG 5 mg
 $119.00
1/EA		 Add To Favorites
45-SML1507-25MG 25 mg
 $480.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H22N6O.ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23);1H/t14-;/m1./s1
InChI key NBKRZGHHBBHLOQ-PFEQFJNWSA-N
Quality Level 100 
SMILES string Cl.[n]1(ncc(c1)c2cc(c(cc2)O)c3nc(ccn3)NC[C@H](N)CC)C
solubility H2O: 15 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: CRT0066101 is a very potent inhibitor of Protein Kinase D (PKD) isoforms with IC50 values for PKD-1, -2 and -3 = 1, 2.5 and 2 nM, respecitively. CRT0066101 has been shown to have anticancer activity. CRT0066101 potently inhibits proliferation of PANC-1 pancreatic cells, and blocks migration and invasion of U87MG glioblastoma cells. CRT0066101 has also been shown to decrease growth of primary tumors and metastasis of ER(-) breast cancers.
Biochem/physiol Actions: CRT0066101 is a very potent inhibitor of Protein Kinase D (PKD) isoforms.
Packaging: 5 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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