CRT0066101 hydrochloride
SIGMA/SML1507 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 956123-34-5 (free base)
Empirical Formula (Hill Notation): C18H22N6O · xHCl
Molecular Weight: 338.41 (free base basis)
Linear Formula: C18H22N6O · xHCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C18H22N6O.ClH/c1-3-14( |
InChI key | NBKRZGHHBBHLOQ-PFEQFJNWSA |
Quality Level | 100 |
solubility | H2O: 15 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | CRT0066101 is a very potent inhibitor of Protein Kinase D (PKD) isoforms with IC50 values for PKD-1, -2 and -3 = 1, 2.5 and 2 nM, respecitively. CRT0066101 has been shown to have anticancer activity. CRT0066101 potently inhibits proliferation of PANC-1 pancreatic cells, and blocks migration and invasion of U87MG glioblastoma cells. CRT0066101 has also been shown to decrease growth of primary tumors and metastasis of ER(-) breast cancers. |
Packaging: | 5 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P301 + P312 + P330 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |