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SR1848

SIGMA/SML1513 - ≥98% (HPLC)

Synonym: 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione; CDI 3238389; ML180

CAS Number: 863588-32-3
Empirical Formula (Hill Notation): C20H25ClN4O2
Molecular Weight: 388.89
MDL Number: MFCD05894342
Linear Formula: C20H25ClN4O2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1513-5MG 5 mg
$120.00
1/EA
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45-SML1513-25MG 25 mg
$490.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H25ClN4O2/c21-15-5-4-8-17(13-15)23-9-11-24(12-10-23)18-14-19(26)25(20(27)22-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,22,27)
InChI key CHMQQIFPOIZPIJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(N(C1CCCCC1)C(N2)=O)C=C2N3CCN(C4=CC(Cl)=CC=C4)CC3
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: SR1848 has been used as a liver receptor homolog 1 (LRH-1) inhibitor to study the role of LRH-1 in the regulation of lipopolysaccharide (LPS)-induced proinflammatory cytokines in mice macrophage. It has also been used as an LRH-1 inhibitor to study its effects on activation-induced Fas ligand (FasL) expression in the murine T-cell hybridoma cell line.
Biochem/physiol Actions: SR1848 is a cell penetrant and potent inhibitor of orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) that reduces the expression of CyclinD1 and E1, which results in inhibition of cell proliferation. SR1848 induces rapid translocation of nuclear LRH-1 to the cytoplasm.
Biochem/physiol Actions: The actions of SR1848 might contribute to anti-cancer functionality.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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