SR1848

SIGMA/SML1513 - ≥98% (HPLC)

Synonym: 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione; CDI 3238389; ML180

CAS Number: 863588-32-3
Empirical Formula (Hill Notation): C₂₀H₂₅ClN₄O₂
Molecular Weight: 388.89
MDL Number: MFCD05894342
Linear Formula: C₂₀H₂₅ClN₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1513-5MG	5 mg	$120.00 1/EA	Add To Favorites
45-SML1513-25MG	25 mg	$490.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C20H25ClN4O2/c21-15-5-4-8-17(13-15)23-9-11-24(12-10-23)18-14-19(26)25(20(27)22-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,22,27)
InChI key	CHMQQIFPOIZPIJ-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(N(C1CCCCC1)C(N2)=O)C=C2N3CCN(C4=CC(Cl)=CC=C4)CC3
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	2-8°C

Application:	SR1848 has been used as a liver receptor homolog 1 (LRH-1) inhibitor to study the role of LRH-1 in the regulation of lipopolysaccharide (LPS)-induced proinflammatory cytokines in mice macrophage. It has also been used as an LRH-1 inhibitor to study its effects on activation-induced Fas ligand (FasL) expression in the murine T-cell hybridoma cell line.
Biochem/physiol Actions:	SR1848 is a cell penetrant and potent inhibitor of orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) that reduces the expression of CyclinD1 and E1, which results in inhibition of cell proliferation. SR1848 induces rapid translocation of nuclear LRH-1 to the cytoplasm.
Biochem/physiol Actions:	The actions of SR1848 might contribute to anti-cancer functionality.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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