Anle138b

SIGMA/SML1515 - ≥98% (HPLC)

Synonym: 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole; 5-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole; Anle 138b; CID 44608289

CAS Number: 882697-00-9
Empirical Formula (Hill Notation): C₁₆H₁₁BrN₂O₂
Molecular Weight: 343.17
Linear Formula: C₁₆H₁₁BrN₂O₂
Product Type: Chemical

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19)
InChI key	RCQIIBJSUWYYFU-UHFFFAOYSA-N
Quality Level	100
SMILES string	BrC1=CC(C2=CC(C3=CC(OCO4)=C4C=C3)=NN2)=CC=C1
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models. Anle138b extends the survival of mice infected with prions. Anle138b strongly inhibits BSE-derived and human prions. The fluorescence strongly increases upon binding with α-synuclein fibrils. Apparently, Anie138b binds to hydrophobic pockets in the fibrils.
Biochem/physiol Actions:	Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation.
Biochem/physiol Actions:	Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregation effects of α-synuclein.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable