Anle138b
SIGMA/SML1515 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 882697-00-9
Empirical Formula (Hill Notation): C16H11BrN2O2
Molecular Weight: 343.17
Linear Formula: C16H11BrN2O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C16H11BrN2O2/c17-12-3- |
InChI key | RCQIIBJSUWYYFU-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | BrC1=CC(C2=CC(C3=CC(OCO4) |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models. Anle138b extends the survival of mice infected with prions. Anle138b strongly inhibits BSE-derived and human prions. The fluorescence strongly increases upon binding with α-synuclein fibrils. Apparently, Anie138b binds to hydrophobic pockets in the fibrils. |
Biochem/physiol Actions: | Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregation effects of α-synuclein. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P302 + P352 - P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |