DS-437

SIGMA/SML1516 - ≥98% (HPLC)

Synonym: 5′-S-[2-[[(Ethylamino)carbonyl]amino]ethyl]-5′-thio-adenosine

CAS Number: 1674364-87-4
Empirical Formula (Hill Notation): C₁₅H₂₃N₇O₄S
Molecular Weight: 397.45
Linear Formula: C₁₅H₂₃N₇O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1516-5MG	5 mg	$108.00 1/EA		Add To Favorites
45-SML1516-25MG	25 mg	$435.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10+,11?,14-/m1/s1
InChI key	CACMCLIHCDTJHL-XNZUMOJTSA-N
Quality Level	100
SMILES string	NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSCCNC(NCC)=O)O3
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Application:	DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.
Biochem/physiol Actions:	DS-437 inhibits regulatory T cells (Tregs) function and methylation of forkhead box P3 (FOXP3) in 293T cells. DS-437 in combination with anti-p185erbB2/neu antibody 4D5 reduces tumor growth in CT26HER2 tumor-bearing mice.
Biochem/physiol Actions:	DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC₅₀ 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.
Other Notes:	DS-437 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the DS-437 probe summary on the Chemical Probes Portal website.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P330 + P331 + P310
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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