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SID 3712249

SIGMA/SML1518 - ≥95% (HPLC)

Synonym: 1,8-Diamino-3,6-di-1-pyrrolidinyl-2,7-naphthyridine-4-carbonitrile; MLS000054131; MiR-544 Inhibitor 1

CAS Number: 522606-67-3
Empirical Formula (Hill Notation): C17H21N7
Molecular Weight: 323.40
MDL Number: MFCD03483890
Linear Formula: C17H21N7
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1518-5MG 5 mg
$108.00
1/EA
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45-SML1518-25MG 25 mg
$348.00
1/EA
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assay ≥95% (HPLC)
color white to brown
form powder
InChI 1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22)
InChI key SSWVPYMSHHEYAB-UHFFFAOYSA-N
Quality Level 100 
SMILES string NC1=C2C(C=C(N3CCCC3)N=C2N)=C(C#N)C(N4CCCC4)=N1
solubility DMSO: 15 mg/mL, clear
storage condition protect from light
storage temp. room temp
Biochem/physiol Actions: SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.
Other Notes: light sensitive
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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