Synonym: 1,8-Diamino-3,6-di-1-pyrrolidinyl-2,7-naphthyridine-4-carbonitrile; MLS000054131; MiR-544 Inhibitor 1
CAS Number: 522606-67-3
Empirical Formula (Hill Notation): C17H21N7
Molecular Weight: 323.40
MDL Number: MFCD03483890
Linear Formula: C17H21N7
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
white to brown |
| form |
powder |
| InChI |
1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22) |
| InChI key |
SSWVPYMSHHEYAB-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
NC1=C2C(C=C(N3CCCC3)N=C2N)=C(C#N)C(N4CCCC4)=N1 |
| solubility |
DMSO: 15 mg/mL, clear |
| storage condition |
protect from light |
| storage temp. |
room temp |
| Biochem/physiol Actions: |
SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir. |
| Other Notes: |
light sensitive |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
