Synonym: GS-39783; N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine; N4,N6-dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
CAS Number: 39069-52-8
Empirical Formula (Hill Notation): C15H23N5O2S
Molecular Weight: 337.44
MDL Number: MFCD06201849
Linear Formula: C15H23N5O2S
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
faintly yellow to dark yellow |
form |
powder |
InChI |
1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) |
InChI key |
GSGVDKOCBKBMGG-UHFFFAOYSA-N |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
CSc1nc(NC2CCCC2)c(c(NC3CCCC3)n1)[N+]([O-])=O |
solubility |
DMSO: 5 mg/mL, clear (warmed) |
storage temp. |
room temp |
Biochem/physiol Actions: |
GS39783 is a positive allosteric modulator (PAM) of GABA-B receptors. GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to modulate GABA release and regulate K+ channels and Ca++ channels. GS39783 has been shown to inhibit alcohol self-administration and to have an antipsychotic-like effect in animal models of addiction and schizophrenia, respectively. |
Packaging: |
5, 25 mg in glass bottle |
Purity |
≥98% (HPLC) |
Storage Temp. |
room temp |
UNSPSC |
12352200 |