Synonym: 7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione; 7-(1,3-Dioxolan-2-ylmethyl)theophylline
CAS Number: 69975-86-6
Empirical Formula (Hill Notation): C11H14N4O4
Molecular Weight: 266.25
MDL Number: MFCD00865218
Linear Formula: C11H14N4O4
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3 |
| InChI key |
HWXIGFIVGWUZAO-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CN1C2=C(N(CC3OCCO3)C=N2)C(N(C)C1=O)=O |
| solubility |
H2O: 2 mg/mL, clear (warmed) |
| storage temp. |
2-8°C |
| Application: |
Doxofylline has been used as a phosphodiesterase (PDE) inhibitor to study its protective effects on lipopolysaccharides (LPS)-induced inflammatory response in human pulmonary bronchial epithelial cells. It has also been used to study its interaction with bovine serum albumin (BSA). |
| Biochem/physiol Actions: |
Doxofylline (also known as doxophylline) has antitussive and bronchodilator effects. Doxofylline is used clinically in the treatment of asthma. Doxofylline has similar efficacy to theophylline, but unlike theophylline or other xanthines has little affinity for adenosine receptors and does not produce stimulant effects and has significantly fewer side effects. |
| Biochem/physiol Actions: |
Doxofylline acts and as a non-selective phosphodiesterase (PDE) inhibitor and exhibits anti-inflammatory activity. It has the potential to treat chronic obstructive pulmonary disease (COPD). |
| General description: |
Doxofylline is a novel xanthine derivative comprising of dioxolone group. |
| Packaging: |
50 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Precautionary statements |
P301 + P312 + P330 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
