Synonym: 15α-Hydroxyestriol; 3,15α,16α,17β-Tetrahydroxyestra-1,3,5(10)-triene; E4; Estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol; Oestetrol
CAS Number: 15183-37-6
Empirical Formula (Hill Notation): C18H24O4
Molecular Weight: 304.38
MDL Number: MFCD00198996
Linear Formula: C18H24O4
Product Type: Chemical
| assay |
≥98% (HPLC) |
| form |
powder |
| InChI |
1S/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12-,13-,14-,15-,16-,17+,18+/m1/s1 |
| InChI key |
AJIPIJNNOJSSQC-NYLIRDPKSA-N |
| Quality Level |
100  |
| SMILES string |
[H][C@@]12CCC3=CC(O)=CC=C3[C@@]1([H])CC[C@@]4(C)[C@@]2([H])[C@@H](O)[C@@H](O)[C@@H]4O |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Estetrol (E4, 15α-Hydroxyestriol) is an estrogen steroid hormone produced exclusively during pregnancy by the fetal liver. Estetrol is a selective estrogen receptor modulator (SERM) with potent estrogenic effects on vaginal mucosa, bone and brain, neutral effect on liver, and anti-estrogen effects on breast tissue. Estetrol has higher affinity for ERα over ERβ. Estetrol is being studied for its potential as a contraceptive, a drug for meopausal symptoms, and an anticancer agent. |
| General description: |
Estetrol is an estrogenic steroid molecule produced exclusively during pregnancy by the fetal liver. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
