Abiraterone acetate

SIGMA/SML1527 - ≥98% (HPLC)

Synonym: CB 7598; 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate

CAS Number: 154229-18-2
Empirical Formula (Hill Notation): C₂₆H₃₃NO₂
Molecular Weight: 391.55
MDL Number: MFCD00934213
Linear Formula: C₂₆H₃₃NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1527-5MG	5 mg	$134.00 1/EA		Add To Favorites
45-SML1527-25MG	25 mg	$543.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1
InChI key	UVIQSJCZCSLXRZ-UBUQANBQSA-N
Quality Level	100
SMILES string	C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CN=C5
solubility	DMSO: 5 mg/mL, clear
storage temp.	−20°C

Application:	Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.
Biochem/physiol Actions:	Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer. Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H360 - H372
Precautionary statements	P201 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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