Iloperidone
SIGMA/SML1528 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 133454-47-4
Empirical Formula (Hill Notation): C24H27FN2O4
Molecular Weight: 426.48
MDL Number: MFCD00866688
Linear Formula: C24H27FN2O4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C24H27FN2O4/c1-16(28)1 |
| InChI key | XMXHEBAFVSFQEX-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Fc1cc2[o]nc(c2cc1)C3CCN(C |
| solubility | DMSO: 5 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. |
| Biochem/physiol Actions: | Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drug’s efficacy on mood and cognition. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H413 |
| Precautionary statements | P273 - P301 + P310 + P330 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |