Iloperidone
SIGMA/SML1528 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 133454-47-4
Empirical Formula (Hill Notation): C24H27FN2O4
Molecular Weight: 426.48
MDL Number: MFCD00866688
Linear Formula: C24H27FN2O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C24H27FN2O4/c1-16(28)1 |
InChI key | XMXHEBAFVSFQEX-UHFFFAOYSA |
Quality Level | 100 ![]() |
solubility | DMSO: 5 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drug’s efficacy on mood and cognition. |
Packaging: | 10, 50 mg in glass bottle |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H301 - H413 |
Precautionary statements | P273 - P301 + P310 + P330 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |