Erdosteine

SIGMA/SML1529 - ≥98% (HPLC)

Synonym: ({2-Oxo-2-[(2-oxotetrahydro-3-thienyl)amino]ethyl}sulfanyl)acetic acid; 2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid

CAS Number: 84611-23-4
Empirical Formula (Hill Notation): C₈H₁₁NO₄S₂
Molecular Weight: 249.31
MDL Number: MFCD00867664
Linear Formula: C₈H₁₁NO₄S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1529-50MG	50 mg	$108.00 1/EA	Add To Favorites
45-SML1529-250MG	250 mg	$435.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)
InChI key	QGFORSXNKQLDNO-UHFFFAOYSA-N
Quality Level	100
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Application:	Erdosteine has been used as a mucolytic to study its protective effects on interleukin-1β-stimulated inflammation in rat chondrocytes in osteoarthritis models.
Biochem/physiol Actions:	Erdosteine is a mucolytic drug with expectorant and antitussive effects. Erdosteine is quickly metabolized in vivo to free thiols which act as free radical scavengers. Erdosteine has also been shown to have antioxidant activity through the activation of Nrf2-dependent antioxidant genes and inhibition of pro-inflammatory cytokines.
General description:	Erdosteine is a derivative of thiol, and is used in the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis.It consists of two blocked sulfhydryl groups, which are released following first-pass metabolism.
Packaging:	50, 250 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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