SB-334867
SIGMA/SML1530 - ≥98% (HPLC)
Synonym: N-
CAS Number: 792173-99-0
Empirical Formula (Hill Notation): C17H13N5O2
Molecular Weight: 319.32
MDL Number: MFCD06411602
Linear Formula: C17H13N5O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C17H13N5O2/c1-10-20-12 |
| InChI key | AKMNUCBQGHFICM-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=C(NC1=CC=C(N=C(C)O2)C2= |
| solubility | DMSO: 5 mg/mL, clear (warmed) |
| storage condition | desiccated |
| storage temp. | room temp |
| Biochem/physiol Actions: | Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867. |
| Biochem/physiol Actions: | SB-334867 is a non-peptide selective antagonist of the orexin OX1 receptor. SB-334867 blocks orexin-A induced calcium response with a pKb of 7.23. SB-334867 blocks increases in heart rate and body temperature induced by administratin of methamphetamine, and can inhibit the development of tolerance to the analgesic properties of morphine in rodent models. SB-334867 also shows anxiolytic and sedative effects. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |