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SB-334867

SIGMA/SML1530 - ≥98% (HPLC)

Synonym: N-(2-Methyl-6-benzoxazolyl)-N′-1,5-naphthyridin-4-yl-urea; SB-334867; SB-334867A; SB334867

CAS Number: 792173-99-0
Empirical Formula (Hill Notation): C17H13N5O2
Molecular Weight: 319.32
MDL Number: MFCD06411602
Linear Formula: C17H13N5O2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1530-5MG 5 mg
$134.00
1/EA
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45-SML1530-25MG 25 mg
$543.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)
InChI key AKMNUCBQGHFICM-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(NC1=CC=C(N=C(C)O2)C2=C1)NC3=CC=NC4=C3N=CC=C4
solubility DMSO: 5 mg/mL, clear (warmed)
storage condition desiccated
storage temp. room temp
Biochem/physiol Actions: Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867.
Biochem/physiol Actions: SB-334867 is a non-peptide selective antagonist of the orexin OX1 receptor. SB-334867 blocks orexin-A induced calcium response with a pKb of 7.23. SB-334867 blocks increases in heart rate and body temperature induced by administratin of methamphetamine, and can inhibit the development of tolerance to the analgesic properties of morphine in rodent models. SB-334867 also shows anxiolytic and sedative effects.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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