Cinaciguat hydrochloride
SIGMA/SML1532 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 646995-35-9
Empirical Formula (Hill Notation): C36H39NO5 · HCl
Molecular Weight: 602.16
MDL Number: MFCD28127267
Linear Formula: C36H39NO5 · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C36H39NO5.ClH/c38-35(3 |
InChI key | LLHMBJOVHATVSP-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | OC(C(C=C1)=CC=C1CN(CCCCC( |
solubility | DMSO: 10 mg/mL, clear |
storage condition | desiccated |
storage temp. | −20°C |
Biochem/physiol Actions: | Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation. |
Biochem/physiol Actions: | Cinaciguat, also known as BAY 58-2667, is a novel activator of guanylate cyclase. It is used in the treatment of acute decompensated heart failure (ADHF). It has been reported that cinaciguat possesses cardiovascular effects. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |