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Cinaciguat hydrochloride

SIGMA/SML1532 - ≥98% (HPLC)

Synonym: 4-[((4-Carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino)methyl[benzoic]acid hydrochloride; 4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid hydrochloride; BAY 58-2667 hydrochloride; BAY582667 hydrochloride; UNII-59K0Y58UAD hydrochloride

CAS Number: 646995-35-9
Empirical Formula (Hill Notation): C36H39NO5 · HCl
Molecular Weight: 602.16
MDL Number: MFCD28127267
Linear Formula: C36H39NO5 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1532-5MG 5 mg
 $244.00
1/EA		 Add To Favorites
45-SML1532-25MG 25 mg
 $977.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C36H39NO5.ClH/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28;/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41);1H
InChI key LLHMBJOVHATVSP-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC2=CC=CC=C2OCC3=CC=C(CCC4=CC=CC=C4)C=C3)=O.[H]Cl
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.
Biochem/physiol Actions: Cinaciguat, also known as BAY 58-2667, is a novel activator of guanylate cyclase. It is used in the treatment of acute decompensated heart failure (ADHF). It has been reported that cinaciguat possesses cardiovascular effects.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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