Synonym: (±)-Maritoclax; 1,1′-(4,4′,5,5′-Tetrachloro[1,3′-bi-1H-pyrrole]-2,2′-diyl)bis[1-(2-hydroxyphenyl)-methanone
CAS Number: 1227962-62-0
Empirical Formula (Hill Notation): C22H12Cl4N2O4
Molecular Weight: 510.15
Linear Formula: C22H12Cl4N2O4
Product Type: Chemical
assay |
≥95% (HPLC) |
color |
light yellow to dark yellow |
form |
powder |
InChI |
1S/C22H12Cl4N2O4/c23-12-9-13(19(31)10-5-1-3-7-14(10)29)28(22(12)26)18-16(24)21(25)27-17(18)20(32)11-6-2-4-8-15(11)30/h1-9,27,29-30H |
InChI key |
QYPJBTMRYKRTFG-UHFFFAOYSA-N |
Quality Level |
100 |
solubility |
DMSO: 20 mg/mL, clear |
storage temp. |
−20°C |
Biochem/physiol Actions: |
Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1, originally isolated from marine streptomycetes for its antimicrobial activity against methicillin-resistant Staphylococcus aureus. Marinopyrrole A directly binds to Mcl-1 and targets it for proteasomal degradation. Marinopyrrole A induced apoptosis in Mcl-1-dependent cancer cells and sensitized cancer cells to ABT-737. |
General description: |
Marinopyrrole A (Maritoclax) is a member of phenolic 1,3′-bipyrroles family targeting actin group. |
Packaging: |
5, 25 mg in glass bottle |
Hazard statements |
H413 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥95% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |