Synonym: (±)-Maritoclax; 1,1′-(4,4′,5,5′-Tetrachloro[1,3′-bi-1H-pyrrole]-2,2′-diyl)bis[1-(2-hydroxyphenyl)-methanone
CAS Number: 1227962-62-0
Empirical Formula (Hill Notation): C22H12Cl4N2O4
Molecular Weight: 510.15
Linear Formula: C22H12Cl4N2O4
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
light yellow to dark yellow |
| form |
powder |
| InChI |
1S/C22H12Cl4N2O4/c23-12-9-13(19(31)10-5-1-3-7-14(10)29)28(22(12)26)18-16(24)21(25)27-17(18)20(32)11-6-2-4-8-15(11)30/h1-9,27,29-30H |
| InChI key |
QYPJBTMRYKRTFG-UHFFFAOYSA-N |
| Quality Level |
100  |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1, originally isolated from marine streptomycetes for its antimicrobial activity against methicillin-resistant Staphylococcus aureus. Marinopyrrole A directly binds to Mcl-1 and targets it for proteasomal degradation. Marinopyrrole A induced apoptosis in Mcl-1-dependent cancer cells and sensitized cancer cells to ABT-737. |
| General description: |
Marinopyrrole A (Maritoclax) is a member of phenolic 1,3′-bipyrroles family targeting actin group. |
| Packaging: |
5, 25 mg in glass bottle |
| Hazard statements |
H413 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
