DMH2

SIGMA/SML1535 - ≥98% (HPLC)

Synonym: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline; VU0364849

CAS Number: 1206711-14-9
Empirical Formula (Hill Notation): C₂₇H₂₅N₅O₂
Molecular Weight: 451.52
Linear Formula: C₂₇H₂₅N₅O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1535-5MG	5 mg	$125.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C27H25N5O2/c1-2-4-26-24(3-1)23(9-10-28-26)25-18-30-32-19-21(17-29-27(25)32)20-5-7-22(8-6-20)34-16-13-31-11-14-33-15-12-31/h1-10,17-19H,11-16H2
InChI key	DXLXRNZCYAYUED-UHFFFAOYSA-N
Quality Level	100
SMILES string	N1(CCOC2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC6=C5C=CC=C6)C=N4)C=C2)CCOCC1
solubility	DMSO: 1 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	DMH2 is a potent antagonist of the BMP receptor activin receptor-like kinase 3 (ALK3, BMPR-IA) that enhance liver regeneration. DMH2 potently inhibits BMP signaling and induced the greatest reduction of cell growth and expression of Id family members in H1299 non-small cell lung carcinoma cells.
Biochem/physiol Actions:	DMH2 is a potent antagonist of the BMP receptor activin receptor-like kinase 3 (ALK3, BMPR-IA).
General description:	DMH2 is a small molecule, which has ability to inhibit BMP type I receptors. The bone morphogenetic proteins (BMP) signal inhibition further decreases expression of Id proteins in lung cells.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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