DMH2
SIGMA/SML1535 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 1206711-14-9
Empirical Formula (Hill Notation): C27H25N5O2
Molecular Weight: 451.52
Linear Formula: C27H25N5O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C27H25N5O2/c1-2-4-26-2 |
InChI key | DXLXRNZCYAYUED-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | N1(CCOC2=CC=C(C(C=N3)=CN4 |
solubility | DMSO: 1 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | DMH2 is a potent antagonist of the BMP receptor activin receptor-like kinase 3 (ALK3, BMPR-IA) that enhance liver regeneration. DMH2 potently inhibits BMP signaling and induced the greatest reduction of cell growth and expression of Id family members in H1299 non-small cell lung carcinoma cells. |
General description: | DMH2 is a small molecule, which has ability to inhibit BMP type I receptors. The bone morphogenetic proteins (BMP) signal inhibition further decreases expression of Id proteins in lung cells. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |