Synonym: 3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione; 3a,7a-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione; 7a-Dimethylhexahydro-3a,4,7-epoxyisobenzofuran; Cantharidine; Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
CAS Number: 56-25-7
Empirical Formula (Hill Notation): C10H12O4
Molecular Weight: 196.20
EC Number: 200-664-3
Linear Formula: C10H12O4
Product Type: Chemical
| biological source |
insect |
| concentration |
0.1 mg/mL in DMSO |
| form |
solution |
| InChI |
1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10- |
| InChI key |
DHZBEENLJMYSHQ-XCVPVQRUSA-N |
| Quality Level |
200  |
| shipped in |
ambient |
| SMILES string |
O1[C@@H]2[C@]3([C@@]([C@H]1CC2)(C(=O)OC3=O)C)C |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
Cantharidin inhibits protein phosphatase 2A. |
| Biochem/physiol Actions: |
It is a component of mylabris, a traditional Chinese medicine. Cantharidin exhibits anti-tumor activity. In addition, cantharidin can work against multidrug-resistant cells. In the epidermis, it causes release of neutral serine proteases, leading to degeneration of the desmosmal plaque. This results in acantholysis and intraepidermal blistering as well as skin lysis. PP2A is involved in the cell cycle, cell death, growth and cell-fate determination. |
| Other Notes: |
Stable for at least two years at 2-8° C. |
| WGK Germany |
WGK 1 |
| Flash Point(F) |
188.6 °F |
| Flash Point(C) |
87 °C |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
