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NMDI14

SIGMA/SML1538 - ≥97% (HPLC)

Synonym: 4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester; Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate

CAS Number: 307519-88-6
Empirical Formula (Hill Notation): C21H25N3O4S
Molecular Weight: 415.51
Linear Formula: C21H25N3O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1538-5MG 5 mg
 $173.00
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45-SML1538-25MG 25 mg
 $599.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI key QRLPSNLBUMVXBL-UHFFFAOYSA-N
Quality Level 100 
SMILES string [s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O
solubility DMSO: 0.2 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:
• to study its effects on differentiating cardiomyocytes
• to study its effects on zebrafish pdzk1 gene-knockout embryos
• to analyze its effects on the apoptosis of colorectal cancer cells
Biochem/physiol Actions: NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.
Biochem/physiol Actions: Potent nonsense-mediated RNA decay (NMD) inhibitor
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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