NMDI14
SIGMA/SML1538 - ≥97% (HPLC)
Synonym: 4,5-
CAS Number: 307519-88-6
Empirical Formula (Hill Notation): C21H25N3O4S
Molecular Weight: 415.51
Linear Formula: C21H25N3O4S
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
solubility | DMSO: 0.2 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Application: | NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor: • to study its effects on differentiating cardiomyocytes • to study its effects on zebrafish pdzk1 gene-knockout embryos • to analyze its effects on the apoptosis of colorectal cancer cells |
Biochem/physiol Actions: | NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |